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Sarcoidosis is an inflammatory disease of unknown etiology. Although it usually affects the lungs, it can also involve other organs, including the central nervous system (CNS). Among the CNS manifestations of sarcoidosis are meningitis and meningoencephalitis. In this study the authors compare the usefulness of computerized tomography (CT) and magnetic resonance imaging (MRI) of the brain in the evaluation of cerebral lesions in patients with neurosarcoidosis. Both CT and MRI were performed in 14 patients with neurosarcoidosis and the findings of these two modalities compared to those of autopsy in 12 patients. The authors found that CT and MRI were concordant in 7 of the 12 autopsies, but in the other 5 cases, CT showed lesions not found on autopsy. In 2 patients CT was normal, while MRI showed lesions. In conclusion, although CT and MRI are the main diagnostic tools in sarcoidosis, they cannot be considered equivalent techniques because they do not detect all of the small “silent” lesions that may occasionally be seen in other cases of sarcoidosis.Authors

Date of this Version

2011

Comments

Abstract

Thioredoxin-dependent peroxiredoxin (TPx) is one of the major enzymes eliminating lipid hydroperoxides (LOOH). The protein is a monomeric enzyme that uses a conserved Cys-Xaa-Xaa-Cys-Cys motif to reduce LOOH. The present report shows that the TRx-TPx complex is formed in a two-step reaction. In the first step, LOOH binds to the TRx active site and forms a TRx-LOOH complex. In the second step, the TRx-LOOH complex

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